Year: 2021 | Month: February | Volume 11 | Issue 1
Molecular Detection and Pathomorphological Studies of Canine Distemper Virus Infection (CDV) in Dogs
Mridusmrita Buragohain
Sushanta Goswami
Probodh Borah
Shameem Ara Begum
Bhaben Chandra Baishya
DOI:10.30954/2277-940X.01.2021.21
Abstract:
In this study RT-PCR was used to detect CDV NP gene from the whole blood samples of dogs clinically suspected for CD followed by the study of pathomorphological alterations in different tissues. Clinical signs such as respiratory distress, purulent oculo-nasal discharge, biphasic fever, gastroenteritis, pustular dermatitis, prominent hyperkeratosis of the digital pads and nervous disorders were observed in the clinically suspected cases. The nervous disorder includes seizure, convulsion, paddling movement, tremor followed by posterior paralysis. On necropsy, bronchopneumonia, congestion and haemorrhages over the mucosal surface of the urinary bladder, stomach, intestine and brain were prominent lesions. Microscopically, both eosinophilic intranuclear and intracytoplasmic inclusion bodies were recorded in the neurons and glial cells, epithelial cells of the bronchioles, urinary bladder, kidney tubules and gastric glands. Congested vessels with haemorrhages were also found in the brain, lungs, stomach, intestine and lymphoid organs.
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